Effect Of Ginger On The Brain Of Diabetes Induced Diabetic...

RESEARCH ARTICLE Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats Gehan El-Akabawyâˆâ€", Wael El-Kholy Menoufia University, Department of Anatomy and Embryology, Faculty of Medicine, Menoufia, Egypt a r t i c l e i n f o Article history: Received 3 August 2013 Received in revised form 17 January 2014 Accepted 31 January 2014 Keywords: Ginger Diabetes Brain Histology Immunohistochemistry s u m m a r y Diabetes mellitus results in neuronal damage caused by increased intracellular glucose leading to oxidative stress. Recent evidence revealed the potential of ginger for reducing diabetes-induced oxidative stress markers. The aim of this study is to investigate, for the first time, whether the antioxidant properties of ginger has beneficial effects on the structural brain damage associated with diabetes. We investigated the observable neurodegenerative changes in the frontal cortex, dentate gyrus, and cerebellum after 4, 6, and 8 weeks of streptozotocin (STZ)-induced diabetes in rats and the effect(s) of ginger (500 mg/kg/day). Sections of frontal cortex, dentate gyrus, and cerebellum were stained with hematoxylin and eosin and examined using light microscopy. In addition, quantitative immunohistochemical assessments of the expression of inducible NO synthase (iNOS), tumor necrosis factor (TNF)-, caspase-3, glial fibrillary acidic protein (GFAP), acetylcholinesterase (AChE), and Ki67 were performed. Our results revealed a protective role ofShow MoreRelatedNatural Dyes11205 Words   |  45 PagespH gt; 11. The highest concentrations of cyanidin are found in the skin of the fruit. [edit] Effects on the human body Cyanidin, like other anthocyanidins, has putative antioxidant and radical-scavenging effects which may protect cells from oxidative damage and reduce risk of cardiovascular diseases and cancer. One theory is that dietary intake of cyanidins may inhibit development of obesity and diabetes as well as contain inflammatory mechanisms.[2] Other studies have generally shown that the glucoside